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猪链球菌耐药性的检测

杨建江1，2， 韩文瑜1， 雷连成1， 杜锐1， 王兴龙1， 江文正1

(1. 解放军军需大学 军事兽医系， 吉林 长春130062；
2. 新疆阿克苏地区质量技术监督局， 新疆 阿克苏843000)

摘要： 采用药敏纸片扩散法、微量稀释法及双纸片扩散法对分离自长春地区的22株猪链球菌进行了耐药性测定。结果表明，82%～100%的菌株对大环内酯林克酰胺链阳菌素B(MLSB)类、四环素类、氟喹诺酮类、氯霉素类、氨基糖苷类耐药，但对青霉素和氨苄青霉素不耐药，对利福平的耐药率为5%；82%的菌株为多重耐药(MDR)；91%的菌株为MLSB型耐药，其中构成型耐药占95%。除青霉素外，其他5种抗生素的MIC50和MIC90高度集中(≥128μg/mL)。

关键词： 猪链球菌； 抗生素； 耐药性

中图分类号：S 859.796  文献标识码： B  文章编号：1000-6419(2004)07-0048-03

Determination of drug resistance in Streptococcus suis isolates

YANG Jianjiang1,2, HAN Wenyu1, LEI Liancheng1, DU Rui1, WANG Xinglong1, JIANG Wenzheng1

(1. Faculty of Military Veterinary, Quartermaster University of PLA, Changchun 130062,China;
2. Aksu Prefecture Technical Supervision Bureau for Quality, Xinjiang 843000,China)

Abstract: The drug resistance of Streptococcus suis isolated from different farms in Changchun was determined by means of the methods of disk diffusion, doubledisk diffusion and microdilution. The results were as follows. The isolates, 5% of which were weakly resistant to rifampin, and 82%-100% of which were strongly resistant to quinolones, chloramphenicol, tetracycline, aminoglycoside and macrolidelincosamidestreptomycin B (MLSB), were not resistant to βacidamide. Hence, 82% of the isolates were multiple drug resistance (MDR), and 91% of them were resistant to phenotype of MLSB. 95% of MLSB phenotype was constitutively resistant (CR). By statistical analysis, MIC50 and MIC90 of the other five antibiotics besides βacidamide focused mainly on high level of resistance area (≥128μg/mL).

Key words: Streptococcus suis; resistance; determination; MIC

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