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鸡球虫疫苗1号的免疫效果研究
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闫鸿斌1，田广孚1，贾万忠1，林青1，2，李辉1，侯俊玲1，郭爱疆1，
程晓红1，宋玉霞1，才学鹏1
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（1.中国农业科学院 兰州兽医研究所 家畜疫病病原生物学国家重点实验室 甘肃省动物寄生虫病重点
实验室，甘肃 兰州730046； 2.西北农林科技大学 动物科技学院，陕西 杨凌712100 )
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摘要：
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用鸡球虫1号苗(LCV-1)以1头份/只和5头份/只剂量分别免疫10日龄伊莎褐公雏，并设攻虫对照组和空白对照组。2个免疫组在整个试验过程中没有死亡，其相对增重率分别达9627%和9517%，而攻虫对照组的相对增重率为9121%，与免疫组相比差异显著；2个免疫组攻虫期间平均OPG值分别为1001×105和163×105，而攻虫对照组为2118×105，2个免疫组与攻虫对照组相比差异极显著；2个免疫组间比较，免疫1组比免疫2组的平均增重高1.1%，差异不显著；免疫期间平均OPG值免疫1组比免疫2组小5308%，差异极显著，攻虫期间前者比后者小3859%，差异显著。从总体看，免疫1组的剂量比免疫2组的安全可靠，免疫保护作用更强。 |
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关键词：
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鸡；球虫病； LCV-1疫苗； 免疫效果 |
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中图分类号：S 852.723
文献标识码：
A 文章编号：1673-4696(2006)04-0292-04 |
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Studies on the efficacy of the live vaccine LCV-1
against chicken coccidiosis |
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YAN Hong-bin1，TIAN Guang-fu1，JIA
Wan-zhong1，LIN Qing1,2，LI Hui1，HOU
Jun-ling1，
GUO Ai-jiang1，CHENG Xiao-hong1，SONG Yu-xia1，CAI
Xue-peng1 |
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（1. Key Laboratory of Veterinary Parasitology of Gansu Province/ State Key Laboratory of Veterinary Etiological
Biology/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046,China；
2.College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100,China） |
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Abstract: Efficacy of the vaccine LCV-1 against chicken coccidiosis was evaluated in two vaccinated groups, challenge group and control group using the indexes of relative ratio of weight gain and OPG . In the vaccinated group 1 and group 2, 10 days-old AsaBrown male chicks were vaccinated with 1 and 5 dose of LCV-1 per bird, respectively. Results showed that percentages of protection against mixed species of Eimeria were 100% in the two vaccinated groups after challenge. The relative ratios of weight gain were 9627% in the vaccinated group 1 and 95.17% in the vaccinated group 2 , which were significantly higher than that in the challenge group (91.21%). After challenge, the OPG in the challenge group (2.118×105) was significantly higher than that in the vaccinated group 1(1.001×105) and in the vaccinated group 2 (1.63×105), but there was no significant difference between the two vaccinated groups. Furthermore, the OPG in the vaccinated group 1 was significantly lower by 53.08% than that in the vaccinated group 2 before challenge, and also significantly lower by 38.59% than that in the vaccinated group 2 after challenge. The results indicated that the vaccinated chickens were resistant against coccidiosis, and the vaccinated group 1 performed better than the vaccinated group 2. |
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Key words: chicken; coccidiosis; LCV-1 vaccine;immuno-efficacy |
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