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双顺反子表达质粒在DNA疫苗研究中的应用
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张淼涛1,2，白华2，童德文2
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(1.安庆师范学院 生物系，安徽 安庆246011; 2.西北农林科技大学 动物科技学院，陕西 杨凌712100)
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摘要：
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简述了DNA疫苗的研究概况，介绍了真核双表达质粒的结构特点及其在基因佐剂和二价DNA疫苗中的应用情况，总结分析了双表达质粒的优点和存在的问题，并对其今后在DNA疫苗中的研究方向和前景进行了展望。 |
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关键词：
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双顺反子表达质粒；DNA疫苗；基因重组 |
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中图分类号：Q 782 文献标识码：
A 文章编号：1673-4696(2006)05-0424-05 |
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Application of dicistronic expression plasmids to DNA vaccines |
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ZHANG Miao-tao1,2, BAI
Hua2, TONG De-wen2 |
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(1.Department of Biology, Anqing Normal College, Anqing 246011, China; 2. College of Animal Science
and Technology, Northwest Sci-Tech University of Agriculture and Forestry, Yangling 712100,China) |
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Abstract: DNA vaccine is a new type vaccine, which can induce cellular and humoral immune responses, and plays an important role in the prevention and control of diseases. In the present article, previous studies on DNA vaccines were briefly reviewed, and the structural characteristics of dicistronic expression plasmid and its application in studies of gene adjuvants and bivalent DNA vaccines were summarized. Advantages and problems of dicistronic expression plasmids were outlined and analyzed. Prospects and future research directions for dicistronic expression plasmids in the development of DNA vaccines were discussed. |
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Key words: dicistronic expression plasmid；DNA vaccine；gene recombination |
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