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脊椎动物Toll样受体的比较生物学

弓莉1,2,顾为望1,蔡建平2

(1.第一军医大学 实验动物中心,广东 广州510515; 
2.广东省农业科学院 兽医研究所 广东省兽医公共卫生公共实验室,广东 广州510640)

摘要:  
从分子结构、基因结构及其染色体定位、信号转导等几方面概述了人类Toll样受体(TLRs)的基本特点,并从比较生物学角度归纳了其他哺乳动物、禽类、鱼类等脊椎动物TLRs的研究进展。
关键词:  
脊椎动物; Toll样受体; 固有免疫; 适应性免疫
中图分类号:Q 959.3 文献标识码:文章编号:1673-4696(2006)06-0507-05

Comparative biology of vertebrate Toll-like receptors

GONG Li1,2, GU Wei-wang1, CAI Jian-ping2

(1.Centre of Laboratory Animals, Southern Medical University, Guangzhou 510515, China; 
2.Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China)

Abstract: The characteristics of human Toll-like receptors(TLRs) were presented and the molecular, genetic and chromosomal localization/mapping of other mammals, birds and fish TLRs were reviewed from the perspective of comparative biology.

Key words: vertebrate; Toll-like receptors; innate immunity; adaptive immunity

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