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樗白皮提取物对小白鼠体内黄嘌呤氧化酶活性的影响
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程富胜1，胡庭俊1，张霞2，董鹏程1，王学智1 ，孟聚诚1
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(1.中国农业科学院 兰州畜牧与兽药研究所 农业部新兽药工程重点实验室，甘肃 兰州730050;
2.甘肃农业大学 生命科学技术学院,甘肃 兰州730070)
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摘要：
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为了研究樗白皮提取物对小白鼠机体内黄嘌呤氧化酶（XOD）活性的影响，将实验动物分为5、10、30g/kg樗白皮提取物灌喂组和正常对照组，对各组动物血清、脾、肝中XOD活性进行了测定。结果，10g/kg樗白皮提取物能够降低小白鼠血清、脾、肝组织中的XOD活性，30g/kg樗白皮提取物能提高上述各组织中的XOD活性，5g/kg樗白皮提取物组小白鼠组织中的XOD活性接近正常对照组。结果表明，不同剂量的樗白皮提取物对小白鼠体内XOD活性的作用不同，低剂量时具有抗氧化作用，高剂量时表现为促氧化作用。 |
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关键词：
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樗白皮提取物；小白鼠；黄嘌呤氧化酶；血清；脾；肝 |
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中图分类号：S 853.74 文献标识码：
A 文章编号：1673-4696(2006)08-0665-03 |
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Effect of extraction of Ailanthus altissima on
xanthine oxidase in mouse |
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CHENG Fu-sheng1,HU Ting-jun1,ZHANG
Xia2,DONG Peng-cheng1,
WANG Xue-zhi1,MENG Ju-cheng1 |
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(1.Key Laboratory of New Animal Medicine Project,Ministry of Agriculture/Lanzhou Institute of Animal
and Veterinary Pharmaceutics Sciences,Lanzhou 730050,China; 2.College of Life Science and Technology,
Gansu Agricultural University,Lanzhou 730070,China) |
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Abstract: To examine the effect of extraction of Ailanthus altissima on xanthine oxidase(XOD) in mouse,the animals were divided into four groups: 5，10，30g/kg and control groups,and activity of XOD in serum,spleen and sliver was detected,respectively.The activity of XOD in serum,spleen and sliver of the mouse treated with 10g/kg of A.altissima extraction was lower than that of the control.At the dose of 30g/kg,the activity of XOD was higher than that of the control.At the dose of 5g/kg,the activity of XOD was similar to that of the control.It was concluded that the different dosages of the extraction had different effect on the activity of XOD,and the extraction could inhibit oxidization at the lower dosage (10g/kg ),but it could promote oxidization at higher dosage(30g/kg). |
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Key words:Ailanthus altissima extraction; mouse; xanthine oxidase; serum; spleen; liver |
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