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疱疹病毒TK基因的研究进展
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葛菡1，程安春1，2*,汪铭书1，2*,朱德康1，2,罗启慧2，贾仁勇2，郭宇飞2，陈孝跃1
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（1.四川农业大学 动物医学院 禽病防治研究中心，四川 雅安625014；
2.动物疫病与人类健康四川省重点实验室，四川 雅安625014）
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摘要：
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简述了疱疹病毒具有表达外源基因的优势，介绍了TK基因作为疱疹病毒化学治疗和构建疱疹病毒基因缺失疫苗的首选靶基因。从TK基因的特点、TK基因的表达调控、TK酶生化特性、TK的功能域等方面做了综合论述，并对其今后的研究和应用前景进行了讨论。 |
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关键词：
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疱疹病毒；胸苷激酶基因；表达调控；生化特性；功能域 |
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中图分类号：S 852.659.1 文献标识码：
A 文章编号：1673-4696(2008)01-0086-05 |
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Research advance in thymidine kinase gene of herpesvirus |
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GE Han1,CHENG An-chun1,2,WANG
Ming-shu1,2,ZHU De-kang1,2,LUO Qi-hui2,
JIA Ren-yong2,GUO Yu-fei2,CHEN Xiao-yue1 |
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(1.Research Center for Avian Diseases,College of Veterinary Medicine,Sichuan Agricultural University,Ya’an
625014,China;2.Key Laboratory of Animal Disease and Human Health of Sichuan Province,Ya’an 625014,China) |
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Abstract: Previous studies on the advantages of herpesvirus in expressing foreign genes were briefly reviewed. It was summarized that thymidine kinase (TK) gene was the preferred target gene for chemical treatment and construction of gene-deleted vaccines. The expression regulation, biochemical characteristics and functional domain of TK were comprehensively reviewed. The prospects for research and application of TK was also discussed. |
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Key words: herpesvirus；thymidine kinase gene；expression regulation；biochemical property；functional domain |
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