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抗菌肽的构效关系及其基因表达调控的研究进展
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王德成，佘敏，佘锐萍*，李文贵，王英华，孙泉
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(中国农业大学 动物医学院，北京100094)
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摘要：
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论述了抗菌肽分子结构与功能之间的关系，抗菌肽的抗菌机制及其基因的表达调控途径，阐明了不同来源的抗菌肽均有相似的抗病机理，但来源不同的抗菌肽有其独特的表达方式及调控途径。认为研究抗菌肽的调控机制，对深入认识机体抵抗病原体的侵袭方式及机理,进而人为调控抗菌肽的表达具有重要意义。 |
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关键词：
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抗菌肽；构效关系；基因表达调控 |
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中图分类号：Q 516 文献标识码：
A 文章编号：1673-4696(2008)03-0268-04 |
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Advances in the studies of structure and function relationship of
antibacterial peptide and regulation of expression ABP gene |
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WANG De-cheng,SHE Min,SHE Rui-ping,LI Wen-gui,WANG Ying-hua,SUN Quan |
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(College of Veterinary Medicine,China Agricultural University,Beijing 100094,China) |
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Abstract: Research advances in antibacterial peptide(ABP) were discussed from the perspectives relationship between molecular structure and function,the antibacterial mechanism and the pathway of gene expression regulation.It was pointed out that the ABPs from different sources had similar antibacterial mechanism,specific expression ways and regulatory pathway.Studies on regulatory mechanism of ABP would help to further understand the invasion way and mechanism against pathogens in organisms,and regulate the ABP expression. |
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Key words: antibacterial peptide(ABP);structure-function relationship；gene expression regulation |
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