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一种新兴的富有生命力的生物技术——蛋白转导
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赵武1,李斌1,梁家幸1,韦平2
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（1.广西兽医研究所 病毒研究室，广西 南宁 530001；2.广西大学 养禽与禽病研究所，广西 南宁 530005）
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摘要：
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综述了蛋白转导的发现、蛋白转导结构域（PTD）的结构组成特点、蛋白转导的作用特点、PTD的作用机理以及蛋白转导的应用前景等。指出蛋白转导是生命科学领域一种新兴的生物技术，其高效的跨膜转运功能和细胞间自主传递的特点彻底打破了常规的基因转移模式，为基因治疗和高效药物与新型疫苗研究开辟了新的途径。 |
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关键词：
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蛋白转导；蛋白转导结构域；作用特点；作用机理；应用前景 |
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中图分类号：S 852.21 文献标识码：
A 文章编号：1673-4696(2008)04-0360-05 |
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An update review on a new promising biotechnology:protein transduction |
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ZHAO Wu1,LI Bin1,LIANG Jia-xing1,WEI
Ping2 |
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(1.Department of Virology,Guangxi Veterinary Research Institute,Nanning 530001,China;
2.Institute for Poultry Science and Health,Guangxi University,Nanning 530005,China) |
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Abstract: Protein transduction as a new biotechnology,was reviewed in the aspects of its discovery,structural and functional characteristics of its protein transduction domain(PTD),and the functional mec-hanism of PTD.The prospects of application of the technique were also discussed.It was pointed out that protein transduction,a unique biology phenomena,was discovered in recent years,and proteins with transduction property can penetrate cellular membrane and transport from the original expressing cell to surrounding nonexpressing cells.Protein transduction not only is a challenge to conventional gene transfer techniques,but also provides the possibility for improvement of gene therapy,medicines,and new-type vaccines. |
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Key words: protein transduction;protein transduction domain;structural characteristics;functional characteristics;applied prospects |
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