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阿莫西林杀灭金黄色葡萄球菌的药代动力学
和药效动力学关系
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杨东，曾振灵，杨雨辉，沈祥广，古小燕，丁焕中*
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（华南农业大学 兽医学院 广东省兽药研制与安全评价重点实验室，广东 广州510642）
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摘要：
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建立了体外药代动力学和药效动力学(PK-PD)模型，测定了阿莫西林杀灭金黄色葡萄球菌的药代动力学参数和药效动力学参数，并研究了它们之间的关系。结果表明，T>最低抑菌浓度(MIC)是衡量阿莫西林药效的关键指标，当阿莫西林浓度超过MIC时，初始浓度0.4～3.2μg/mL对杀灭金黄色葡萄球菌的药效没有影响。在消除半衰期为2h的模型内，T>MIC在7.40h以上时阿莫西林对金黄色葡萄球菌有较好的杀灭效果；在消除半衰期为5.5h的模型内，T>MIC在11.76h以上时阿莫西林对金黄色葡萄球菌有较好的杀灭效果。 |
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关键词：
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阿莫西林；金黄色葡萄球菌；药代动力学；药效动力学 |
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中图分类号：S 859.796 文献标识码：
A 文章编号：1673-4696(2008)05-0438-05 |
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Pharmacokinetics-pharmacodynamics relationship of
amoxicillin against Staphylococcus aureus |
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YANG Dong,ZENG Zhen-ling,YANG Yu-hui,SHEN Xiang-guang,GU Xiao-yan,DING Huan-zhong
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(Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation/
College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China) |
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Abstract: A pharmacokinetics-pharmacodynamics model in vitro was developed,and the pharmacokinetics-pharmacodynamics relationship of amoxicillin against Staphylococcus aureus was described by the model.The results showed that T>MIC was recognized as the most important parameter of amoxicillin for antibacterial efficacy.While the initial concentrations of amoxicillin exceeded MIC,the concentrations from 0.4μg/mL to 3.2μg/mL did not influence the effect of antibacterial action.In elimination half-life model of 2 hours,the antibacterial efficacy of amoxicillin against S.aureus was good while the value of T>MIC exceeded 7.40h.In elimination half-life model of 5.5 hours,the antibacterial efficacy of amoxicillin against S.aureus was excellent while the value of T>MIC exceeded 11.76h.
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Key words: amoxicillin；Staphylococcus aureus；pharmacokinetics;pharmacodynamics |
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