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弓形虫棒状体蛋白的研究进展
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刘苗苗，周鹏，朱兴全*
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（华南农业大学 兽医学院，广东 广州510642）
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摘要：
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综述了弓形虫棒状体蛋白在弓形虫侵入宿主细胞和对宿主细胞毒力方面的研究进展，对部分棒状体蛋白作为疫苗候选分子的研究进行了概述，并对棒状体蛋白在疫苗研制方面的潜力进行了展望。表明，弓形虫棒状体蛋白对弓形虫侵入宿主细胞起重要作用，是研制弓形虫病疫苗的候选分子。 |
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关键词：
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刚地弓形虫；棒状体蛋白；疫苗 |
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中图分类号：S 852.723 文献标识码：
A 文章编号：1673-4696(2008)05-0443-04 |
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Advances in the studies on rhoptry proteins of Toxoplasma gondii |
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LIU Miao-miao,ZHOU Peng,ZHU Xing-quan |
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(College of Veterinary Medicine,South China Agricultural University，Guangzhou 510642,China) |
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Abstract: The recent advances were reviewed in the studies of rhoptry proteins (ROPs) secreted by the rhoptry of Toxoplasma gondii involved in invasion of host cell by T.gondii and virulence.The achievements in the studies of some ROPs as candidates for the development of vaccines against toxoplasmosis were summarized.The potencies of ROPs for the development of vaccines against toxoplasmosis were prospected.It is concluded that ROPs play an important role during host cell invasion and they are potential candidates for the development of vaccines against toxoplasmosis. |
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Key words: Toxoplasma gondii;rhoptry protein;vaccine |
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